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KMID : 1007020070050020072
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Korean Soceity of Osteroporosis
2007 Volume.5 No. 2 p.72 ~ p.77
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The Effect of Tibolone on Bone Density in Women with Early Menopause Resulting from Cancer Treatment
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Lee Dong-Ok
Kang Sok-Bom
Park Sang-Yoon
Seo Sang-Soo
Kim Seul-Ki
Chung Youn-Kyung
Bae Jae-Man
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Abstract
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Objectives: To evaluate the effect of tibolone on bone density in women with early menopause (<45 years old) resulting from treatment of cervical cancer.
Methods: Through retrospective chart review, 13 women with early menopause resulting from bilateral oophorectomy or pelvic radiation therapy were compared with age-matched healthy women. All the women had taken tibolone continuously. Two normal women were matched per one woman with early menopause, so 26 of healthy women with regular menstruation were selected. Initial bone density data of lumbar spine, femur neck, and total hip were compared with those of two years later.
Results: For 2 years, there were no significant changes in bone density of women treated with tibolone for early menopause. In normal control, bone density of total hip was significantly decreased after 2 years. (P=0.02) In inter-group analysis, there were no significant differences in changes of bone density between two groups.
Conclusion: Women treated with tibolone for early menopause kept normal age-related change in bone density. Tibolone may be effective for prevention of bone loss in women with early menopause after bilateral oophorectomy or pelvic radiation therapy.
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KEYWORD
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Earlly llmenopause, Bone density, Tibolone, Oophorectomy, Radiation therapy
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